Abstract: Based on the linear theory of wave interactions with a large-scale vertical bottom-mounted cylinder, using the method of transfer functions, a number of models of multi-directional random wave interaction with a large-scale cylinder were established. A wave basin experiment was carried out, and the numerical calculation results were verified by the results of the physical experiment. The results from the numerical calculation and the experiment were essentially identical. The results show that wave directional distribution has significant effects on wave run-up when multi-directional irregular waves interact with a cylinder. Results can provide reference for the design of appropriate engineering projects.