Abstract: A continuous subsection independently systematic integral method (CSISIM for short) is presented for solving coupled cable-beam optimization design problems in cable-stayed bridges. First, without considering the cable-beam deformation compatibility conditions, we solve the bending moment analytical functions of a six time statically indeterminant four-span coupled cable-continuous beam problem by CSISIM. And then, by making the bending moment at the cable’s acting point equal to zero, we get the internal force state of the dead load for a cable-stayed bridge with a drop frame. By combining the minimum bending energy method and CSISIM, the optimal cable force solution is quickly obtained. Lastly, considering the cable-beam deformation compatibility conditions, we solve a ten times statically indeterminant four-span coupled cable-continuous beam problem by CSISIM. The analytic functions of shear force, bending moment, angle, and deflection are obtained. The engineering example shows that establishing a model using CSISIM is simple. Computer programming is systemized, so optimal analysis solutions can be quickly obtained.