Abstract: With regard to a six-tower cable-stayed bridge- Jiashao Bridge, the nonlinear wind-induced buffeting response of the bridge was analyzed through time domain analysis based on the transient dynamics analysis of ANSYS. The buffeting response characteristics of the main girder and bridge towers under strong wind action were investigated and the influences of wind-excited force and bridge tower wind effect on the main girder and bridge towers were investigated respectively. The analysis results reveal that: 1) The wind-induced buffeting responses of the main girder and bridge towers are closely related with the structural dynamic properties. Due to the dynamic coupling action between the main girder and bridge towers, the structural buffeting responses present certain uniqueness; 2) Due to the effect of wind-excited force, the vertical buffeting response of the main girder becomes obviously smaller, but the transverse and torsional buffeting displacements have little difference. For bridge towers, the wind-excited force has no effect on the transverse buffeting response, but it plays a significant role in reducing the longitudinal buffeting response; 3) The bridge tower wind effect has no effect on the vertical and torsional buffeting displacement of the main girder and the longitudinal buffeting response of bridge towers, but it makes significant difference in the transverse buffeting responses of the main girder and bridge towers.