Abstract: Transient analysis of five reinforced concrete frame-core tube structures with different structural characteristics was carried out under several sets of ground motions. The relationship between hysteretic energy and structural characteristics as well as seismic parameters was derived. The interlayer distribution of hysteretic energy among continuous beams and frames were studied. Results show that ratio of structure vibration period to the predominant period of seismic waves and the peak ground acceleration have great influences on hysteretic energy. The stiffness eigenvalue affects the distribution of hysteretic energy within the framework and the core wall. The ratio of linear stiffness between the continuous beam and the shear wall is linearly correlated to the ratio of hysteretic energy between them. It is found that the hysteretic energy is mostly concentrated to lower layers of shear walls and the middle of continuous beams. Parameter studies and regression analysis were conducted to formulate simplified formulations of interlayer distribution of hysteric energy, which is to reflect the structural stiffness eigenvalue, the ratio of stiffness between continuous beam and shear wall, and structural vibration period.