Abstract: Cable-stayed-suspension systems are characterized by the obvious three-dimensional ambient flow under wind action, which is actually a kind of complex wind effect. The cable-stayed-suspension system is sensitive to wind action and is prone to vibration due to its long span and flexibility. Taking the aerobus systems as engineering background, the aerodynamic coefficients of the main cable and guideway are firstly measured by a wind tunnel test with an 1∶1 scale section model. Then, considering the interactions of wind, cable and guideway, the secondary development of the finite element software ANSYS has been carried out. The whole process of wind induced static and dynamic responses is simulated by automatical loading on the basis of the nonlinear three-dimensional finite element model of wind, cable and guideway. Finally, the static and dynamic responses of the cable and the guideway are obtained. The results show that the structure is flexible, and the lateral displacement of the cable and guideway is comparatively large at the design wind speed. The lateral response is dominated and much larger than the vertical response. The research conclusions can provide a reference for the design optimization of long span cable-stayed-suspension systems.