Abstract: Based on the human knee model with prosthesis, finite element models of the knee model with prosthetic implantation deflections in standing position after total knee arthroplasty are built. Finite element simulations are performed to investigate the effects of the prosthetic implantation deflections in total knee arthroplasty on the mechanical characteristic of knee articular surfaces. The prosthetic implantation deflections include the deflections of medial-lateral translation, anterior-posterior translation, internal-external rotation and varus-valgus rotation of femoral component. The results show that varus deflection of the femoral component affects the Contact Press distribution and maximum Von Mises stress of the femoral component obviously. Therefore, varus-valgus rotation angle should be controlled to the minimum level to decrease the effects of the changes of stress distribution between the knee articular surfaces on the wear of polyethylene tibial component. This study can provide reference information concerning the wear of polyethylene tibial component and surface design of antiwear prosthesis.