Abstract: The seismic response analysis method of transmission tower in consideration of pile-soil-structure dynamic interaction is presented. Pile-soil-transmission tower coupled system is set up with visco-elastic artificial boundary as the soil boundary and modified Goodman element as the pile-soil interaction face. The seismic response of a pile-soil-transmission tower system under four different site conditions is calculated, and compared with the results that do not consider the effect of pile-soil-structure dynamic interaction. It can be concluded that the displacement of tower and the stress of the members substantially increased on soft sites and medium soft sites while no significant change on medium hard sites and hard sites when pile-soil-structure dynamic interaction is considered. Therefore it is suggested that the pile-soil-structure dynamic interaction should be fully considered in aseismic design of transmission tower on soft sites and medium soft sites.