Abstract: With the rapid developments of offshore oil and gas explorations, the construction of subsea pipelines is becoming more and more in China. Due to the long-term effects of loading and enviromental factors, the material aging and damage accumulation may lead to the deteriation of strcural status and load-bearing capacity for subsea pipelines. To keep the safe serive, the safety management of subsea pipelines should be established during the life-cycle operation. Fistly, the critical issues on life-cycle service for subsea pipelines were analyzed in the paper. Then the research activities in Dalain University of Technology were briefly reviewd for the damage mechanism as well as structural health monitoring of subsea pipelines. Finally, the issues for future research were put forward.