Abstract: The uniformly modulated evolutionary function is introduced for the seismic response analysis of a self-anchored suspension bridge with the non-stationary seismic excitation amplitudes and the seismic spatial varying ground motion effect including wave passage effect, ground motion coherence loss and local-spatial variation ground effect taken into account. The bending moment and shearing force of the tower are investigated under stationary and non-stationary ground excitations. It can be verified that the seismic response peak values are decreased under non-stationary excitation. By taking into account wave passage effect and coherence loss, the seismic response peak values are increased.