Abstract: The wind-induced response of prestressed double-layer cylindrical reticulated shells is researched based on the time-domain analytical method. The Welch spectrum analysis method is presented to evaluate the power spectrum accuracy of the fluctuating wind speed time-history simulated by the harmony superposition method and linear filter technique (AR method). The influence of structural design parameters on the wind-induced response is investigated, including rise-span-ratio, span, thickness, length-width-ratio and the elastic support stiffness of the structure. Results show that the rise-span-ratio, span and length-width-ratio are the main factors influencing the structural wind-induced response. The existing of prestressed cable efficiently reduces the fluctuating wind induced response of the structure, while the displacement wind vibration coefficient is still greater than that of common non-prestressed reticulated shells since the average wind induced response is also reduced greatly. The global wind vibration coefficient method is introduced based on the envelope concept, which takes the maximum structural vibration response and maximum average wind induced response as controlled indexes. In the end, the global wind vibration coefficients of prestressed double-layer cylindrical reticulated shells under various design parameters are calculated.