Abstract: When the steel frames are installed with Buckling-Restrained Braces (BRBs), whose aseismic performance will be improved, but the function of energy dissipation and vibration control is influenced by the layout principle of BRBs. The elastoplastic static and dynamic analysis based on ANSYS was carried out. Based on 9 storey Benchmark steel frame structure, the influence of three layout principles of BRBs on structural aseismic performance was analyzed. While the BRBs are disposed by the basis of the stiffness proportion of BRBs with steel frames and storey displacement angle distributions, the ductility performance of the steel frame with BRBs is better. If the storey displacement angles are more uniform, the stiffness and energy dissipation are larger when the BRBs are disposed based on the stiffness proportion of BRBs with steel frames. So when the steel frame with BRBs is designed, it is appropriate that the BRBs are disposed by the basis of the stiffness proportion of BRBs with the steel frame.