Abstract: The deformation of aluminum single crystal including a cylindrical void under plain strain pressure was designed to investigate the growth behavior of void in FCC crystals. The heterogeneous deformation and the change of crystallographic orientation around the void were studied by using electron backscatter diffraction, integrating with crystal plasticity finite element method, and the deformation behavior of aluminum single crystal including a cylindrical void was simulated by compiling a user material subroutine program with rate-dependent crystal plasticity theory. Experimental results and simulation results show that the crystallographic orientation has significant influence on the growth behavior of voids. The rate-dependent crystal plasticity finite element method can well simulate the void growth behavior and the change of crystallographic orientation around the void in FCC crystals, and it can be used to analyze void evolution and fractural behavior of materials.