Abstract: In this paper, the conjugative heat transfer in a regenerative cooling structure is investigated numerically by using the FEM and CFD software. The distribution and evolution of the temperature in the solid and coolant, the interfacial heat flux, and the stress state and the deformation of this cooling structure are obtained. These results show that the thermal equilibrium of the cooling structure can be achieved in a given flow condition, and the water is more effective as a coolant by comparing with the kerosene. At the same time, an obvious stress concentration is exhibited in the corner of a rectangular pipeline, which prompts a more elaborate designing of this cooling structure.