Abstract: The seismic reliability of concrete perforated brick masonry structure is studied. Based on the peak acceleration distribution related with probability of earthquake intensity, the formula of the structure seismic reliability in the earthquake zone is proposed, and a discrete method is obtained. By considering the most horizontal displacement and the cumulative energy damage, a new double-parameters criterion based on the early experiment is derived. The seismic safety performance of concrete perforated brick masonry structure in the different earthquake intensity fortification area and its influence factor are analyzed.