Abstract: In order to improve the effect of shock absorption and the application range of base-isolated structure with lead rubber bearing (LRB) and study the influence of the action of coupling earthquake in both horizontal and vertical direction to vibration control structures, three kinds of hybrid projects with magnetorheological damper (MRD) and LRB are proposed in the paper. The governing differential equation for the hybrid structure with MRD and LRB under the action of coupling earthquake in both horizontal and vertical direction is set up. Seismic response analysis of a 7-storey hybrid structure with MRD and LRB is carried out. Compared with sliding base-isolated structure, all of the peak values of various seismic responses of three hybrid projects are reduced. The results of dynamic analysis show that the seismic responses of hybrid structure with MRD and LRB get better control than sliding base-isolated structure under various loading conditions and that the control effect of the third hybrid project is the best.