Abstract: In order to investigate the seismic performance of Guangdong science Centre, a model of area E in Guangdong science Centre with scale of 1∶35 is fabricated and tested on the large-scale shaking-table with 3 dimensions and 6 degrees of freedom. Based on the test, the self-shaking properties, damping ratios, seismic responses are investigated, and the seismic responses of the prototype structure are analyzed.