Abstract: Taking the commercial CFD software-Fluent as a numerical simulation platform, the simulation method and sensibility of parameters pertinent to the aerodynamic forces acting on the thin flat plate in static and dynamic conditions are studied in detail. On the basis of an optimized computational domain and reasonable basic parameters, aerodynamic force coefficients of the flat plate in static state at different attack angles are analyzed and aerodynamic forces of the flat plate in motion state are also simulated. Calculation results agree with theoretical results well. Further the effect of wind speeds, turbulence models, the flakiness ratio, the motion of plates, the frequency and amplitude of oscillations on aerodynamic forces are explored respectively. The conclusions can supply reference to increase the accuracy of CFD for bridges and structures.