Abstract: This paper constructs a dynamic response analysis model for a closed loop control system of an intelligent beam structure with random uncertainties. The random approach is introduced for the random dynamic response analysis of the closed loop control system. With the Duhamel integral for dynamic responses and the Moment method for random variable function solutions, the numerical characteristic expressions are deduced for transversal displacement, angle displacement and stress responses. Finally, an intelligent cantilever beam is taken as an example to explain the influence of random structural parameters and random loads on dynamic responses of the closed loop control system. The results also show the feasibility and rationality of the random coefficient method.