Abstract: Standing seam roof system is more and more widely used in large-span space structures, but it is sensitive to wind loads, which has led to many wind-lifting accidents and caused significant losses. In order to study the wind damage mechanism and wind failure probability of standing seam aluminized-zinc steel roof system, this research was carried out in terms of dynamic and static wind uplift tests, numerical simulation, and wind disaster vulnerability analysis by taking the Transportation Center of Urumqi Tianshan International Airport as the research object. The study shows that: the wind resistance of the roof system is significantly affected by the board width, support spacing and wind clamp; the wind damage process of the roof system is divided into four stages, i.e., elastic stage, plastic platform stage, plastic development stage and damage, and then the damage index is defined; the damage indices of 0.2, 0.6, and 1.0 are used as the three performance levels to classify these four stages of damage, and the wind disaster vulnerability analysis is carried out based on the Latin hypercubic sampling and regression analysis method; combined with the wind tunnel test data, the wind disaster vulnerability curves of the roof cover of the transportation center in each wind direction angle are investigated, and the results point out that the wind direction angle of 30° is the most unfavorable direction for the roof cover of the transportation center. The above study can provide reference value for the design of wind resistance of standing seam aluminized-zinc steel roof system.