Abstract: The anchor box type cable-girder anchorage structure, which is one of the common anchorage forms for large span cable-stayed bridges, has a complex structure with many welds and is susceptible to fatigue damage under fatigue loads such as vehicles and wind. Meantime, the salt spray corrosive environment formed inside the anchor box will further accelerate the deterioration of the fatigue performance of the anchorage zone. In order to study the influence of corrosion effects on the fatigue performance of anchor box cable-girder anchorage zone, the surface pitting pit model of typical components in the anchorage zone was derived using the cellular automata model, which can reflect the electrochemical mechanism of corrosion in the paper. The cable-stayed bridge of Runyang Yangtze River Highway Bridge at the north branch was taken as the engineering case to establish the finite element model of long-span cable-stayed bridge considering the corrosion surface roughness. A fatigue vehicle model was established based on the field measured vehicle data, and the influence of typical anchor box corrosion on the fatigue performance of cable-girder anchorage structure under the action of the fatigue vehicle model was investigated. With the cellular automata model that reflects the nature of electrochemistry, instead of the traditional engineering approach of uniformly discounting thickness to consider corrosion effects, the effects of surface roughness and stress concentration at the bottom of corrosion pits on the deterioration of the performance of corroded components can be fully considered. Stress analysis of the overall structure of a long-span cable-stayed bridge can ensure the accuracy of stress distribution in anchorage zone. The research method fully considers the electrochemical effect of corrosion and the influence of actual vehicle load on the mechanical properties of cable-girder anchorage zone. The results show that the fatigue life of the anchor box type cable-girder anchorage structure is reduced by 21.18%, 26.99% and 6.3%, respectively, under the corrosion degree of 10% mass loss rate of the anchor box bottom plate, upper web and lower web, compared with those without considering the corrosion effect. The corrosion effect can greatly reduce the fatigue life of the anchor box type anchorage structure, which needs full attention.