Abstract: Aiming to study the blast-resistant performance of ultra-high performance concrete-filled steel tube (UHPC-FST) pier columns under typical blast threats: Full parameters of K&C (Karagozian & Case) model were comprehensively calibrated according to the existing experimental data of UHPC. The finite element models were established in LS-DYNA based on the previous blast and axial compression tests of UHPC-FST pier columns. The material models and parameters and finite element analysis approach were validated by comparing the numerically predicted damage profiles and axial force-displacement curves of the pier column with the test results. According to the Federal Emergency Management Agency (FEMA), three explosion threats were selected including suitcase, compact sedan, and cargo van bomb. The blast performances of seismically designed UHPC-FST and RC pier columns were numerically studied. The results indicate that: both two piers are controlled by local damage under contact explosion of the suitcase bomb, and the residual axial load capacities of the RC and UHPC-FST piers are reduced by 85% and 6.5% compared to the initial values, respectively; under compact sedan explosive, the RC and UHPC-FST pier columns are separately dominated by local and global damages, and the residual axial load capacities of which are decreased by 83% and 24%, respectively; under cargo van explosive, both two types of piers suffer severe damage and lose the axial load capacities.