Abstract: The creep performance of GFRP structures is concerned in the bridge engineering field because the resin in GFRP components belongs to the polymer material, which affects its promotion and application in the infrastructure engineering sector. This study focused on the E-GFRP lamina. The creep behavior of E-GFRP unidirectional lamina were predicted by using fiber and resin creep behavior through the two-scale numerical homogenization simulation method. The accuracy of the prediction was verified by comparing the experimental results with pertinent numerical simulation. The effects of stress level, the fiber volume fraction, and loading direction on the creep performance of E-GFRP lamina were analyzed. The results show that the higher the stress level or the smaller the fiber volume ratio is, the greater the creep strain of the lamina becomes. Then, a creep strain model of E-GFRP lamina with different fiber volume ratios was proposed to accurately describe the relationship between stress level and loading time and creep strain. Finally, the creep fracture time prediction equation of E-GFRP lamina was proposed, which may provide a reference for engineering design and long-term behavior prediction of E-GFRP structures.