Abstract: Employing the wind tunnel test of synchronous multi-pressure measurement system, the present research investigates the wind pressure, power spectral density (PSD) of wind loads, and wind force coefficient of drum-shaped high-rise buildings with a corner roundness ratio of 25% and 50%, respectively. Meanwhile, the interference effect of two drum-shaped buildings with different distance and corner roundness ratio is examined for two configurations, i.e., parallel and tandem arrangements. Results show that the roundness can reduce the mean wind pressure at the rounded windward corner and make the peak of fluctuating wind pressure move windward, causing considerable peak suction at the windward rounded corner. When the long side is perpendicular to the approaching wind, Strouhal number of the cross-wind loads of drum-shape building is larger than that of the associated rectangular building, and Strouhal number increases with roundness ratio. When the short side is perpendicular to the approaching wind, PSDs of the cross-wind loads of the two drum-shaped buildings show two peaks: the dominant one is at fB/V_h = 0.03, and the other minor one caused by the secondary vortex shedding is at fB/V_h = 0.25. When two drum-shape buildings are in the parallel arrangement, the wind suction on the two inner faces is increased significantly by the channeling effect, especially for the buildings with corner roundness ratio of 50%. When two drum-shaped buildings are in the tandem arrangement, the shielding effect of the upstream buildings decreases the wind pressure on the windward face of the downstream building. In addition, the wind suction of the windward end of the downstream building is far smaller than that of the single isolated building because of the wake flow of the upstream building.