Abstract: Wind tunnel tests and an artificial generation method were used to measure the wind pressure time-history response of a 220 m-high super large cooling tower, and a structural model is established based on the domestic standard and eigenvalue buckling. Finally, the finite element method was used to analyze the wind load dynamic wind resistance characteristics. The analysis results indicate that the response of artificial wind pressure is larger than that of wind tunnel tests. The overall displacement and each layer stress of the extracted unit by the artificial generation method have a large fluctuation. Under the action of dynamic wind loading, the maximum deformation of the structure is located in the throat of the windward tower, and the maximum stress is located in the lower part of the windward tower. The results can provide a reference for the revision of the surface wind load of the super-large cooling tower and relevant technical specifications.