Abstract: A coupling numerical simulation method of CFD/CSD is presented. Taking lift force characteristics as a restriction design object, the coupling aerodynamic and structural design optimization on the configurations of lightweight F4 models manufactured by Stereo-Lithography (SL) was accomplished. Six design optimization configurations of the models were conducted by utilizing the self-created program optimization of response surface methodology. The models with different wing configurations optimization were fabricated by SL technique. The results indicate that the lift force characteristics of the models are accord with the overseas results including static aero-elastic modification, especially that the experimental results of 6# model present that the wings’ deformations are in three-dimensional directions, which shows the coupling aerodynamic and structural design optimization method is feasible. The method can provide some fundaments and supports for the application of lightweight models based on SL for high-speed wind-tunnel test, also can give some suggestions and thoughts to study coupling aerodynamic and structural design optimization for aircrafts based on some aerodynamic parameters and static aero-elastic modifications on aerodynamic data obtained in the experiments.