Abstract: A high strength steel fabricated framed-tube structure with replaceable shear links (HSS-SFTS) was proposed in this paper. A preliminary design method of HSS-SFTS was presented. The finite element models (FEMs) of one 40-story framed tube structure (FTS) and one 40-story HSS-SFTS were established in SAP2000. Static elastoplastic analyses were performed to assess their seismic performance. The analysis results indicate that the inter-story drift of the HSS-SFTS at rare earthquake performance point was less than the corresponding value of the FTS. The inter-story drift angles of the HSS-SFTS could satisfy the requirements of the inter-story deformation limit during frequent earthquakes and the requirement for collapse prevention in the seismic design code. The plastic hinges of the HSS-SFTS at the shear links occurred in the life safety state. When the ultimate strength and the inter-story drift angle distribution of the HSS-SFTS along height was relatively uniform, its plastic deformation and damage were mainly concentrated in the shear link, and it exhibits an ideal overall failure mode. The HSS-SFTS could reduce the effects of earthquakes and the damage to non-dissipative components. The HSS-SFTS could be more prone to functional recovery after earthquakes.