Abstract: To find out the deformation characteristics and damage mechanism of compressed Tibetan-style stone masonry, an experimental research was carried out on 2 groups (8 specimens in all) stacked prisms under axial compression. One group simulates normal rubble stone masonry and the other simulates the Tibetan-style stone masonry. The crack and deformation characteristics, the failure modes, and the complete stress-strain curves were obtained. The research results show that the Tibetan-style stone masonry have staged deformation and damage characteristics, and the complete stress-strain curve is different from other types of masonry. Based on the experimental phenomena and the experimental data, the compressive constitutive relationship before cracking of the Tibetan-style stone masonry is proposed. The equations can be expressed by a two-segment curve with quadratic polynomials. The constitutive relationship is close to the experimental results. The applicability of prism testing was discussed. Suggestions for follow-up tests were proposed.