Abstract: In order to study the wave pressure acting on the vertical breakwater with various incident wave directions, a 3-D numerical wave pool is established based on FLOW-3D software, and a corresponding physical model test is carried out for the validation of the numerical model. The numerical model uses apiston-type plate to generate waves and a pore structure to absorb waves. The results of numerical simulation agree well with the experimental results. The comparison analysis shows that both wave pressure and wave suction of measuring points on the wall increase with the incident angle increasing. At the bottom of the wall, the change trend of the uplifting pressure is more complex, which is no longer applicable described by the Goda's formula. The distribution of wave pressure on the wall is basically consistent with the Goda's formula. And the distribution shape of the uplifting pressure at the bottom of the wall is similar to a trapezoid rather than a triangle described by the Goda's formula. The negative wave pressure distribution under oblique waves is similar to that at forward incidence on the wall. The results can provide a reference for the breakwater design in costal engineering.