Abstract: The building isolation structure is mainly used to weaken the influence of the earthquake on the superstructure. The upper impact, from the aircraft crash on the containment with the isolation system, is also an important issue to ensure the safety of nuclear power station. In order to evaluate the coupling dynamic effect of the isolation system and aircraft crash, a detailed dynamic numerical model of the containment has been established in the paper. Moreover, dynamic response analysis of the containment suffering three different types of aircraft crash is carried out under the conditions of three different isolation bearings and non-isolation. The results show that some changes occur to the displacement of the center node at the impact position which is related to the magnitude of the impact force during the period of aircraft crash. While the distribution of damage area has little change. However, the stiffness of the vibration isolation bearings has great impact on the containment-vibration-attenuation process after the impact load of aircraft. Based on this study, in the stage of isolation system design, it is essential to consider the isolation performance of isolated system as well as the influence of the aircraft impact to determine the appropriate parameters of vibration isolation bearings.