Abstract: In order to study the seismic response of hinge in frame-style curved girder bridge, a 3D model of actual bridge in high seismic region in American is established in OpenSees. Time history analysis is performed to study the seismic response of hinge and the impact of earthquake excitation angle on seismic response. The results show that longitudinal restrained steels and transverse compressive pads are seismic fragile components. Concrete located at the anchor zone of longitudinal restrained steels and the tensile zone of occlusal area in hinge is liable to crack. Different hinges in unsymmetrical bridge have significantly different seismic responses, though the difference is small in symmetrical bridge. Longitudinal excitation generates serious damage of longitudinal restrained devices and large vertical response of occlusal area, but it can homogenize damage of transverse restrained devices in different hinges. Transverse excitation generates serious damage of transverse restrained devices and large transverse response of occlusal area, but it can also homogenize the damage of longitudinal restrained devices in different hinges.