Abstract: Shock wave/boundary layer interaction (SWBLI) is a ubiquitous phenomenon encountered in hypersonic flow fields, and the flow separation it induces leads to performance degradation of hypersonic inlets. In this paper, the separation bubble which is induced by SWBLI in hypersonic flow (Ma=7) is simulated using DES (detached eddy simulation) and the finite volume method. The generation mechanism and development process of separation bubbles are revealed. The separation bubble was also controlled by an MVG array, and the flow field structures, wall pressure, wall shear stress, and the loss of total pressure when one is used are all discussed. The results indicate that an MVG array can suppress the separation bubble which is induced by hypersonic SWBLI; the strength of separation shock is weakened as the size of the separation bubble decreases; the streamwise velocity gradients of the separation bubble and its downstream are increased; the reduction of the loss of total pressure can reach 1.9%.