Abstract: The dynamic responses of single-layer reticulated domes are analyzed through the explicit dynamic finite element software AUTODYN. The load is applied using the FSI method, and the material is adopted using a multi-segment linear model for steel. First, the accuracy is verified by analyzing near-field and far-field explosions. Then the responses of a 20m span reticulated dome are obtained under external blast loading, including the loading spread, change in maximum nodal displacement, and development of plastic members. The laws governing structural response are researched, accounting for the mass of TNT, explosion distance, and explosion height. The results of numerical simulations indicate that AUTODYN can be used to analyze near-field and far-field explosions; the reticulated dome experiences two main shock wave loadings under external blast loading and the maximum nodal displacement occurs at the first shock wave loading; the plasticity development of structural members ends at 0.05 seconds; the structural responses strengthen with the increase of TNT mass and the explosion height, but weaken with the increase of explosion distance.