Abstract: The fluid-solid interaction (FSI) between crosswind and moving vehicles has an impact on driving safety. An arbitrary Lagrange-Euler method is applied to the FSI numerical simulation of a 1:1 double-deck coach model. A dynamic model for six-degrees-of-freedom systems is put into use to simplify the coach model. The systems are simulated under three typical crosswind forms (linear cross-wind, pseudo-jump cross-wind, sine cross-wind) respectively. FSI effect influences the lift force and the yawing moment more notably than other components of general forces, caused by the change of a flow field structure. Through the research, how much the FSI effect influence the general forces respectively can be quantitatively known. It provides a reference to simulate the vehicle travelling status in a more precise way.