Abstract: The seismic fragility of high-rise steel frame-concrete core-wall structures was studied in this paper. Based on the performance-based fragility analysis method, four performance level limits of seismic demand parameters were proposed according to the ultimate damage states of the structures. Considering the randomness of input ground motions, the relationship between the two seismic demand parameters and ground motion intensity indicators was obtained through nonlinear dynamic time history analysis. Combined with the specified limits of performance levels, the vulnerability analysis method was put forward, by which the seismic structural response could be assessed effectively. Seismic fragility analysis was carried out for two high-rise hybrid structures with different connection forms, and fragility curves were obtained to assess and to compare the seismic performances of the two structures.